HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → (1R,6S)-8-(3-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 2-Chloro-4-(trifluoromethyl)pyrimidine | HCID 2773912 | — |
| Reactant | HCID 67116508 | HCID 67116508 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | (1R,6S)-8-(3-Methylpyrazin-2-yl)-3,8-diazabicyclo[4.2.0]octane | HCID 67116913 | — |
Reaction Steps
The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-chloro-3-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine. In addition, DMF and K2CO3 at 95° C. was used in place of DIPEA and ACN.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08680275B2 |
| Source dataset | uspto-grants-2014_03 |
| ORD ID | ord-288c73417fe44ba1a28da2a9cb500103 |
| Source note | uspto-grants-2014_03 |