huagongshe.com
HRID1193083

反应详情

EQUATION

反应方程式

HRID 1193083 的结构方程式

REACTANTS

反应物

4
结构：O=C([O-])[O-].[K+].[K+]
HCID11430

Potassium Carbonate

CK2O3

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：FC(F)(F)c1ccnc(Cl)n1
HCID2773912

2-Chloro-4-(trifluoromethyl)pyrimidine

C5H2ClF3N2

结构：FC(F)(F)c1ccnc(N2C[C@@H]3CCNC[C@@H]32)n1
HCID67116508

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nccnc1N1C[C@@H]2CCNC[C@@H]21
HCID67116913

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CN(C)C=O
溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CC#N
溶剂HCID6342

Acetonitrile

C2H3N

PROCEDURE

实验过程

The title compound was prepared in a manner analogous to Intermediate 27, substituting 2-chloro-3-methylpyrazine for 2-chloro-4-(trifluoromethyl)pyrimidine. In addition, DMF and K2CO3 at 95° C. was used in place of DIPEA and ACN.

WORKUP

后处理

  1. customat 95° C.