Methanol → HCID 67086519, compound

HRID 1193114Notes

Reaction equation

HRID 1193114 reaction equation
[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]2[C:5]([O:7][C:8](=[O:9])[C:3]=12)=[O:6].[CH3:13][OH:14]>>[F:1][C:2]1[CH:12]=[CH:11][CH:10]=[C:4]([C:5]([O:14][CH3:13])=[O:6])[C:3]=1[C:8]([OH:7])=[O:9]

Participants

3

Reactant 2

HCID 887MethanolHCID 695513-Fluorophthalic anhydride

Product 1

HCID 67086519HCID 67086519, compound

Procedure

3-Fluorophthalic anhydride (377 mg, 2.27 mmol) was dissolved in MeOH (6 mL) and heated to reflux for 15 h. The mixture was concentrated in vacuo and the two products (400 mg, 89%), 2-fluoro-6-(methoxycarbonyl)benzoic acid and 3-fluoro-2-(methoxycarbonyl)benzoic acid, were taken on to the next step without purification.

Workup

  1. temperatureheated
  2. temperatureto reflux for 15 h
  3. concentrationThe mixture was concentrated in vacuo
  4. customthe two products (400 mg, 89%), 2-fluoro-6-(methoxycarbonyl)benzoic acid and 3-fluoro-2-(methoxycarbonyl)benzoic acid, were taken on to the next step without purification

Sources & evidence

ORD record
ord-b2cdc1a0204140329e635c505aa258b2
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

Loading…