2-Chloro-6-methylnicotinic acid → 4-(1H-1,2,3-Triazol-1-yl)nicotinic acid

HRID 1193126Notes

Reaction equation

HRID 1193126 reaction equation
CC1C=CC(C(O)=O)=C([N:11]2[N:15]=[CH:14][CH:13]=[N:12]2)N=1.Cl[C:17]1[C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=[CH:19][CH:18]=1.ClC1N=C(C)C=CC=1C(O)=O>>[N:12]1([C:17]2[C:22]([C:23]([OH:25])=[O:24])=[CH:21][N:20]=[CH:19][CH:18]=2)[CH:13]=[CH:14][N:15]=[N:11]1

Participants

4

Reactant 3

HCID 1217242-Chloro-6-methylnicotinic acidHCID 8182294-Chloronicotinic acidHCID 670868556-Methyl-2-[1,2,3]triazol-2-yl-nicotinic acid

Product 1

HCID 670869954-(1H-1,2,3-Triazol-1-yl)nicotinic acid

Procedure

The title compound was prepared in a manner analogous to Intermediate 47 substituting 4-chloronicotinic acid for 2-chloro-6-methylnicotinic acid. MS (ESI):

Sources & evidence

ORD record
ord-20febbc00b6e4b4eb9b6991e856c74aa
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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