6-Chloro-N-cyclopropylpyrimidin-4-amine → HCID 67116854, compound

HRID 1193207Notes

Reaction equation

HRID 1193207 reaction equation
C12N(C3C=NC4C(=CC=CC=4)N=3)CC1CCNC2.[C@@H:19]12[NH:26][CH2:25][C@@H:24]1[CH2:23][CH2:22][N:21]([C:27]([C:29]1[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=1[N:36]1[N:40]=[CH:39][CH:38]=[N:37]1)=[O:28])[CH2:20]2.Cl[C:42]1[CH:47]=[C:46]([NH:48][CH:49]2[CH2:51][CH2:50]2)[N:45]=[CH:44][N:43]=1>>[CH:49]1([NH:48][C:46]2[CH:47]=[C:42]([N:26]3[C@@H:19]4[C@@H:24]([CH2:23][CH2:22][N:21]([C:27]([C:29]5[CH:34]=[C:33]([F:35])[CH:32]=[CH:31][C:30]=5[N:36]5[N:40]=[CH:39][CH:38]=[N:37]5)=[O:28])[CH2:20]4)[CH2:25]3)[N:43]=[CH:44][N:45]=2)[CH2:51][CH2:50]1

Participants

4

Reactant 3

HCID 223094796-Chloro-N-cyclopropylpyrimidin-4-amineHCID 67116560(1R,6S)-3,8-diazabicyclo[4.2.0]octan-3-yl(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanoneHCID 671166512-(3,8-Diaza-bicyclo[4.2.0]oct-8-yl)-quinoxaline

Product 1

HCID 67116854HCID 67116854, compound

Procedure

The title compound was prepared in a manner analogous to Intermediate 2, Step A, using (1R,6S)-3,8-diazabicyclo[4.2.0]octan-3-yl(5-fluoro-2-(2H-1,2,3-triazol-2-yl)phenyl)methanone and 4-chloro-6-(cyclopropylamino)pyrimidine. MS (ESI) mass calcd. for C22H23FN8O, 434.5; m/z found, 435.2 [M+H]+.

Sources & evidence

ORD record
ord-58bb2991968540058d7457f1493e052f
Source dataset
uspto-grants-2014_03
Patent number
US08680275B2

Reaction notes

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