反应详情

N,N-Dibenzyl-2-(piperidin-4-yl)ethanamine (2.4 g, 7.79 mmol, 1 eq) and 4-bromopyridine HBr (1.97 g, 10.12 mmol, 1.3 eq) were dissolved in n-butanol (30 ml) and DIPEA (3.3 ml, 19.47 mmol, 2.5 eq) and the mixture was refluxed for 48 h. After monitoring by thin-layer chromatography, the reaction solution was concentrated under reduced pressure and the residue was taken up in dichloromethane (100 ml), washed with water and sat. NaCl solution (in each case 50 ml), dried over sodium sulfate and concentrated under reduced pressure. After purification by column chromatography (silica gel, 3.5% MeOH in dichloromethane), a white solid was obtained. Yield: 53% (1.6 g, 4.15 mmol).

1. concentrationthe reaction solution was concentrated under reduced pressure
2. washwashed with water and sat. NaCl solution (in each case 50 ml),
3. dry with materialdried over sodium sulfate
4. concentrationconcentrated under reduced pressure
5. customAfter purification by column chromatography (silica gel, 3.5% MeOH in dichloromethane)
6. customa white solid was obtained