Hydrochloric Acid → HCID 66799052, compound

Participants

Reaction Conditions

Reaction Steps

(S)-tert-Butyl 1-(1-cyclopropylpiperidin-4-yl)pyrrolidin-3-ylcarbamate (0.87 g, 2.282 mmol) was dissolved in methanol (4.6 ml), and HCl in methanol (1.25 M, 9.1 ml) was added. The reaction mixture was heated for 3 h at 50° C. and then stirred overnight at RT. The resulting precipitate was filtered off. The filtrate was concentrated to half, and diethyl ether was added. The resulting precipitate was filtered off again. Yield: >99% (0.72 g).

Provenance & Evidence