Hydrochloric Acid → HCID 66799052, compound

HRID 1193307Notes

Reaction equation

HRID 1193307 reaction equation
[CH:1]1([N:4]2[CH2:9][CH2:8][CH:7]([N:10]3[CH2:14][CH2:13][C@H:12]([NH:15]C(=O)OC(C)(C)C)[CH2:11]3)[CH2:6][CH2:5]2)[CH2:3][CH2:2]1.[ClH:23]>CO>[ClH:23].[ClH:23].[ClH:23].[CH:1]1([N:4]2[CH2:5][CH2:6][CH:7]([N:10]3[CH2:14][CH2:13][C@H:12]([NH2:15])[CH2:11]3)[CH2:8][CH2:9]2)[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66805329HCID 66805329, compound

Product 1

HCID 66799052HCID 66799052, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent2×

Conditions

Temperature
50 °C

Procedure

(S)-tert-Butyl 1-(1-cyclopropylpiperidin-4-yl)pyrrolidin-3-ylcarbamate (0.87 g, 2.282 mmol) was dissolved in methanol (4.6 ml), and HCl in methanol (1.25 M, 9.1 ml) was added. The reaction mixture was heated for 3 h at 50° C. and then stirred overnight at RT. The resulting precipitate was filtered off. The filtrate was concentrated to half, and diethyl ether was added. The resulting precipitate was filtered off again. Yield: >99% (0.72 g).

Workup

  1. filtrationThe resulting precipitate was filtered off
  2. concentrationThe filtrate was concentrated to half, and diethyl ether
  3. additionwas added
  4. filtrationThe resulting precipitate was filtered off again

Sources & evidence

ORD record
ord-a35ad658654e47679e8e5e69681acfd2
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

Loading…