Acetyl chloride → HCID 66798574, compound

HRID 1193316Notes

Reaction equation

HRID 1193316 reaction equation
[CH3:1][N:2]([CH:10]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:11]1)C(=O)OC(C)(C)C.C([Cl:24])(=O)C>C(O)C>[ClH:24].[ClH:24].[CH3:1][NH:2][CH:10]1[CH2:14][CH2:13][N:12]([C:15]2[CH:20]=[CH:19][N:18]=[CH:17][CH:16]=2)[CH2:11]1

Participants

4

Reactant 2

HCID 6367Acetyl chlorideHCID 66805330HCID 66805330, compound

Product 1

HCID 66798574HCID 66798574, compoundYield 94%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

tert-Butyl methyl(1-(pyridin-4-yl)pyrrolidin-3-yl)carbamate (3.028 mmol, 1 eq) was dissolved in ethanol (11 ml), and acetyl chloride (15.14 mmol, 5 eq) was added, while cooling with ice. After stirring for 16 h at RT, a solid precipitated. Ethanol was concentrated slightly, and the precipitate was filtered off, washed with diethyl ether and dried. Yield: 94%.

Workup

  1. temperaturewhile cooling with ice
  2. customa solid precipitated
  3. concentrationEthanol was concentrated slightly
  4. filtrationthe precipitate was filtered off
  5. washwashed with diethyl ether
  6. customdried

Sources & evidence

ORD record
ord-98f0969a04dc413f8977e58dd73fb29d
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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