反应详情

TFA (2.78 ml) was added dropwise at 0° C. to a solution of tert-butyl 4-(2-(benzyl(methyl)-amino)ethyl)piperidine-1-carboxylate (600 mg, 1.8 mmol, 1 eq) in dichloromethane (30 ml), and stirring was carried out for 1 h at RT. After monitoring by thin-layer chromatography, the reaction mixture was concentrated to dryness. The residue was dissolved in MeOH (50 ml), Amberlyst A-21 ion-exchanger resin (2 g) was added, and stirring was carried out for 30 min. The reaction mixture was filtered and the filtrate was concentrated to dryness under reduced pressure and used in the next stage without being purified further.

1. concentrationthe reaction mixture was concentrated to dryness
2. dissolutionThe residue was dissolved in MeOH (50 ml)
3. additionAmberlyst A-21 ion-exchanger resin (2 g) was added
4. stirringstirring
5. waitwas carried out for 30 min
6. filtrationThe reaction mixture was filtered
7. concentrationthe filtrate was concentrated to dryness under reduced pressure
8. customwithout being purified further