Trifluoroacetic acid → N-Benzyl-N-methylpiperidin-4-amine

HRID 1193368Notes

Reaction equation

HRID 1193368 reaction equation
[CH2:1]([N:8]([CH3:22])[CH:9]1[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH2:1]([N:8]([CH3:22])[CH:9]1[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]1)[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 23292008tert-Butyl 4-(benzyl(methyl)amino)piperidine-1-carboxylate

Product 1

HCID 1096081N-Benzyl-N-methylpiperidin-4-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(benzyl(methyl)amino)piperidine-1-carboxylate (1.2 g, 3.947 mmol, 1.0 eq.) was dissolved in DCM (10 ml); TFA (1.2 ml) was added at 0° C. and the mixture was stirred for 2 hours at RT. The reaction mixture was concentrated under reduced pressure, taken up several times in toluene and dried. The crude product was used in the next stage without being purified further.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

Sources & evidence

ORD record
ord-109dfd95b04a4856ba46e66ccd9cef07
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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