Trifluoroacetic acid → Benzyl methyl(piperidin-4-yl)carbamate

HRID 1193373Notes

Reaction equation

HRID 1193373 reaction equation
[CH2:1]([O:8][C:9]([N:11]([CH3:25])[CH:12]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]1)=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:25][N:11]([CH:12]1[CH2:13][CH2:14][NH:15][CH2:16][CH2:17]1)[C:9](=[O:10])[O:8][CH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 57753905HCID 57753905, compound

Product 1

HCID 18677746Benzyl methyl(piperidin-4-yl)carbamate

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-((benzyloxycarbonyl)(methyl)amino)piperidine-1-carboxylate (0.3 g, 0.682 mmol, 1.0 eq.) was dissolved in DCM (10 ml); TFA (2.5 ml) was added at 0° C. and stirring was carried out for 2 hours at RT. The reaction mixture was concentrated under reduced pressure, taken up several times in toluene and dried. The crude product was used in the next stage without being purified further.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

Sources & evidence

ORD record
ord-8e1110e4de924ff7a4f9d7cb88be3303
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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