Trifluoroacetic acid → HCID 66798716, compound

HRID 1193391Notes

Reaction equation

HRID 1193391 reaction equation
[C:1]([C:3]1[CH:8]=[C:7]([N:9]2[CH2:14][CH2:13][CH:12]([N:15](C)[C:16](=O)OC(C)(C)C)[CH2:11][CH2:10]2)[CH:6]=[CH:5][N:4]=1)#[N:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[CH3:16][NH:15][CH:12]1[CH2:11][CH2:10][N:9]([C:7]2[CH:6]=[CH:5][N:4]=[C:3]([C:1]#[N:2])[CH:8]=2)[CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66805420HCID 66805420, compound

Product 1

HCID 66798716HCID 66798716, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 1-(2-cyanopyridin-4-yl)piperidin-4-yl(methyl)carbamate (300 mg, 0.949 mmol, 1.0 eq.) was dissolved in DCM (10 ml); TFA (2 ml) was added at 0° C. and stirring was carried out for 2 hours at RT. The reaction mixture was concentrated under reduced pressure, taken up several times in toluene and dried. The crude product was used in the next stage without being purified further.

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customdried
  3. customwithout being purified further

Sources & evidence

ORD record
ord-363e89a666324d88921147b0a27910d9
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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