Trifluoroacetic acid → N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

HRID 1193394Notes

Reaction equation

HRID 1193394 reaction equation
FC(F)(F)C(O)=O.[CH3:8][N:9]([CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1)C(=O)OC(C)(C)C>ClCCl>[CH3:8][NH:9][CH:17]1[CH2:22][CH2:21][N:20]([C:23]2[N:24]([CH3:28])[CH:25]=[CH:26][N:27]=2)[CH2:19][CH2:18]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66798554tert-Butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate

Product 1

HCID 62131647N-methyl-1-(1-methyl-1H-imidazol-2-yl)piperidin-4-amine

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Trifluoroacetic acid (1 ml) was added at 0° C. to a solution of tert-butyl methyl(1-(1-methyl-1H-imidazol-2-yl)piperidin-4-yl)carbamate (241 mg, 0.82 mmol, 1 eq) in dichloromethane (5 ml), and the reaction mixture was stirred for 1 h at room temperature. Concentration under reduced pressure was then carried out. The crude product so obtained was used in the next stage without being purified further.

Workup

  1. concentrationConcentration under reduced pressure

Sources & evidence

ORD record
ord-291a5f2cf6774ef689cf7e3b58fdc86f
Source dataset
uspto-grants-2014_03
Patent number
US08680159B2

Reaction notes

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