反应详情

A mixture of 4-chloro-2-methoxy-6-methylpyrimidine (300 mg, 1.8987 mmol, 1 eq), benzyl methyl(piperidin-4-yl)carbamate (stage 3 AMN-52) (470 mg, 1.8987 mmol, 1 eq) and K2CO3 (523 mg, 3.796 mmol, 2 eq) in acetone (10 ml) was refluxed for 16 h. When the reaction was complete according to TLC monitoring, filtration over Celite was carried out and the filtrate was concentrated under reduced pressure. The crude product was purified by column chromatography (silica gel, 2% methanol/dichloromethane). The desired product was in the form of a light-yellow solid. Yield: 71% (500 mg, 1.3513 mmol)

1. temperaturewas refluxed for 16 h
2. filtrationWhen the reaction was complete according to TLC monitoring, filtration over Celite
3. concentrationthe filtrate was concentrated under reduced pressure
4. customThe crude product was purified by column chromatography (silica gel, 2% methanol/dichloromethane)