反应详情

A solution of benzyl 1-(2,6-dimethylpyrimidin-4-yl)piperidin-4-yl(ethyl)carbamate (960 mg, 2.6 mmol, 1.0 eq) in MeOH (40 ml) was degassed for 15 minutes with nitrogen; Pd(OH)2 (480 mg) was added and hydrogenation was carried out for 1 hour at RT. After monitoring by TLC, the reaction mixture was filtered off over Celite and washed with MeOH (100 ml) and the filtrate was concentrated under reduced pressure and dried. Yield: 66% (400 mg, 1.709 mmol) C. Single Substance Syntheses General Method for the Synthesis of the Illustrative Compounds (H)

1. filtrationthe reaction mixture was filtered off over Celite
2. washwashed with MeOH (100 ml)
3. concentrationthe filtrate was concentrated under reduced pressure
4. customdried
5. customSingle Substance Syntheses General Method for the Synthesis of the Illustrative Compounds (H)