Hydrochloric Acid → HCID 13672713, compound

HRID 1193450Notes

Reaction equation

HRID 1193450 reaction equation
Cl[C:2]1[N:7]=[C:6](Cl)[N:5]=[C:4]([NH:9][C:10]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]2[CH:23]=[N:24][O:25][CH:26]=2)(=[O:15])=[O:14])=[O:11])[N:3]=1.[CH3:27][O-:28].[Na+].Cl.[CH3:31][OH:32]>O>[CH3:27][O:28][C:2]1[N:7]=[C:6]([O:32][CH3:31])[N:5]=[C:4]([NH:9][C:10]([NH:12][S:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=2[C:22]2[CH:23]=[N:24][O:25][CH:26]=2)(=[O:15])=[O:14])=[O:11])[N:3]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 10942334Sodium MethoxideHCID 13672712HCID 13672712, compound

Product 1

HCID 13672713HCID 13672713, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 1 g of sulfonamide prepared in Example 15 in 10 ml of methanol is added portionwise 0.41 g of sodium methoxide. After an initial exotherm, the suspension is stirred at 25° to 50° C. for about 1 hour, then cooled to room temperature and diluted with excess water (about 30 ml). The solution is acidified to a pH of about 1 with concentrated HCl. The resulting mixture is filtered and suction dried to give the title compound.

Workup

  1. filtrationThe resulting mixture is filtered
  2. customsuction dried

Sources & evidence

ORD record
ord-1eab4729172640799e3c77dc93b7cd90
Source dataset
uspto-grants-1989_03
Patent number
US04810282

Reaction notes

Loading…