Potassium Carbonate → 1-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfinylpropyl)piperazine

HRID 1193493Notes

Reaction equation

HRID 1193493 reaction equation
Cl.Cl.[CH3:3][N:4]1[C:12](=[O:13])[C:11]2[N:10]([CH2:14][CH:15]([OH:34])[CH2:16][N:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][S:26]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[O:27])[CH2:19][CH2:18]3)[CH:9]=[N:8][C:7]=2[N:6]([CH3:35])[C:5]1=[O:36].C(=O)([O-])[O-].[K+].[K+]>CCOCC>[CH3:3][N:4]1[C:12](=[O:13])[C:11]2[N:10]([CH2:14][CH:15]([OH:34])[CH2:16][N:17]3[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][S:26]([C:28]4[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=4)=[O:27])[CH2:19][CH2:18]3)[CH:9]=[N:8][C:7]=2[N:6]([CH3:35])[C:5]1=[O:36]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 212721011-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfinylpropyl)piperazine dihydrochloride

Product 1

HCID 144575171-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfinylpropyl)piperazine

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

1.0 g of 1-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfinylpropyl)piperazine dihydrochloride suspended in 50 ml of ether is stirred with excess dilute aqueous potassium carbonate solution until the salt is completely dissolved. The organic layer is then separated, washed twice with water, dried over magnesium sulfate and evaporated to yield 1-[3-(1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dion-7-yl)-2-hydroxypropyl]-4-(3-phenylsulfinylpropyl)piperazine as the free base.

Workup

  1. dissolutionis completely dissolved
  2. customThe organic layer is then separated
  3. washwashed twice with water
  4. dry with materialdried over magnesium sulfate
  5. customevaporated

Sources & evidence

ORD record
ord-6becb012ed664f3a9c8ba4d30bf34fc2
Source dataset
uspto-grants-1989_03
Patent number
US04810706

Reaction notes

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