反应详情

温度

-5 °C

2.6 g of 2-oxo-5-ethoxy pyrrolidine is dissolved in 80 cm3 of anhydrous tetrahydrofuran, then cooled to -5° C., and 12.6 cm3 of butyllithium is added. After 20 minutes under agitation, there is added slowly at the same temperature, 4.05 g of styrene-sulphonyl chloride (CA 47, 3262c (1953)) in 10 cm3 of tetrahydrofuran. After allowing this to return to ambient temperature, after 4 hours, it is concentrated to dryness and the residue is chromatographed on silica. 1.3 g of the expected product is obtained, which is crystallized from a mixture of ethyl ether and hexane. m.p.=61°-63° C.

1. concentrationit is concentrated to dryness
2. customthe residue is chromatographed on silica