HCID 21272305, compound → HCID 21272366, compound

HRID 1193516Notes

Reaction equation

HRID 1193516 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([NH:9][C:10]2[CH:14]=[CH:13][N:12]([C:15]3[CH:27]=[CH:26][C:18]([O:19][CH2:20][C:21]([O:23]CC)=[O:22])=[CH:17][CH:16]=3)[N:11]=2)=[CH:5][CH:4]=1>C(O)C.[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([NH:9][C:10]2[CH:14]=[CH:13][N:12]([C:15]3[CH:27]=[CH:26][C:18]([O:19][CH2:20][C:21]([OH:23])=[O:22])=[CH:17][CH:16]=3)[N:11]=2)=[CH:7][CH:8]=1

Participants

4

Reactant 1

HCID 21272305HCID 21272305, compound

Product 1

HCID 21272366HCID 21272366, compoundYield 92%

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

Ethyl 4-[3-(4-methoxyphenylamino)-1H-pyrazol-1-yl]phenoxyacetate (1.0 g) in ethanol (200 ml) and 10% sodium hydroxide (5 ml) was heated to reflux for 1 hour. Upon cooling, the resultant pink solid was filtered off and treated with a little 10% hydrochloric acid to give a violet solid which was filtered off, rinsed with water and dried to give the title compound (0.85 g), mp 163°-165°.

Workup

  1. temperatureto reflux for 1 hour
  2. temperatureUpon cooling
  3. filtrationthe resultant pink solid was filtered off
  4. additiontreated with a little 10% hydrochloric acid
  5. customto give a violet solid which
  6. filtrationwas filtered off
  7. washrinsed with water
  8. customdried

Sources & evidence

ORD record
ord-1cf55d9e3da6434897c99ce88cdbd115
Source dataset
uspto-grants-1989_03
Patent number
US04810719

Reaction notes

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