Ethyl chloroacetate → HCID 21272323, compound

HRID 1193519Notes

Reaction equation

HRID 1193519 reaction equation
[C:1]1([N:7]2[CH:11]=[CH:10][C:9]([NH:12][C:13]([NH2:15])=[S:14])=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl[CH2:17][C:18](OCC)=[O:19]>C(O)C>[C:1]1([N:7]2[CH:11]=[CH:10][C:9]([NH:12][C:13]3[S:14][CH:17]=[C:18]([OH:19])[N:15]=3)=[N:8]2)[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=1

Participants

4

Reactant 2

HCID 7751Ethyl chloroacetateHCID 21272346HCID 21272346, compound

Product 1

HCID 21272323HCID 21272323, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of N-(1-phenyl-1H-pyrazol-3-yl)thiourea (4.2 g) and ethyl 2-chloroethanoate (3.0 g) in ethyl alcohol (50 ml) was heated under reflux for 2 hours. The mixture was cooled and the title compound collected by filtration as a yellow solid 4.0 g, mp >230°.

Workup

  1. temperatureunder reflux for 2 hours
  2. temperatureThe mixture was cooled
  3. filtrationthe title compound collected by filtration as a yellow solid 4.0 g, mp >230°

Sources & evidence

ORD record
ord-fccf0ea7eff1459cbc059a37ff6cc01c
Source dataset
uspto-grants-1989_03
Patent number
US04810719

Reaction notes

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