反应详情

In a 3 neck, round-bottomed flask reflux a mixture of 11.6 g (0.17 mol) imidazole, 30 g (0.17 mol) 3-bromomethylthiophene, 46 g (0.33 mol) K2CO3 and 400 ml dry acetone. After refluxing for 4 hours filter the reaction mixture and wash the inorganic solids with acetone. Remove the acetone under vacuum and partition the residue betwen H2O/EtOAc. Wash the EtOAc layer several times with H2O, dry (Na2SO4) and concentrate the washed material to obtain a pale yellow oil.

1. temperatureIn a 3 neck, round-bottomed flask reflux
2. temperatureAfter refluxing for 4 hours
3. filtrationfilter the reaction mixture
4. washwash the inorganic solids with acetone
5. customRemove the acetone under vacuum
6. custompartition the residue betwen H2O/EtOAc
7. washWash the EtOAc layer several times with H2O
8. dry with materialdry (Na2SO4)
9. concentrationconcentrate the washed material
10. customto obtain a pale yellow oil