Hydrochloric Acid → HCID 21272622, compound

HRID 1193568Notes

Reaction equation

HRID 1193568 reaction equation
[C:1]([C:3]1[N:4]([CH2:8][C:9]2[CH:13]=[CH:12][O:11][CH:10]=2)[CH:5]=[CH:6][N:7]=1)#[N:2].Cl>[Pd].C(O)C>[NH2:2][CH2:1][C:3]1[N:4]([CH2:8][C:9]2[CH:13]=[CH:12][O:11][CH:10]=2)[CH:5]=[CH:6][N:7]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21272628HCID 21272628, compound

Product 1

HCID 21272622HCID 21272622, compound

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Place 4.0 g (0.021 mol) 2-cyano-1-(3-furylmethyl)-1H-imidazole, 20 ml ethanolic HCl, 20 ml ethanol and 1 g 10% Pd/C in a Parr hydrogenator with an initial pressure of 52 psi. After 18 hours remove the reaction mixture from the Parr hydrogenator, add 20 ml H2O, remove the catalyst by filtration, concentrate the filtrate to obtain an off-white solid which is recrystallized from ethanol containing a little concentrated HCl to give the desired product as a white solid.

Workup

  1. customAfter 18 hours remove the reaction mixture from the Parr hydrogenator
  2. additionadd 20 ml H2O
  3. customremove the catalyst
  4. filtrationby filtration
  5. concentrationconcentrate the filtrate
  6. customto obtain an off-white solid which
  7. customis recrystallized from ethanol containing a little concentrated HCl

Sources & evidence

ORD record
ord-6c0325f14d2b48079460410540d27d47
Source dataset
uspto-grants-1989_03
Patent number
US04810800

Reaction notes

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