4-Toluenesulfonyl chloride → HCID 14581312, compound

HRID 1193605Notes

Reaction equation

HRID 1193605 reaction equation
[F:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][CH2:13]O)[CH:5]=[C:6]([F:10])[C:7]=1[O:8][CH3:9].S(Cl)(C1C=CC(C)=CC=1)(=O)=O.[N-:26]=[N+:27]=[N-:28].[Na+]>>[F:1][C:2]1[CH:3]=[C:4]([CH2:11][CH2:12][CH2:13][N:26]=[N+:27]=[N-:28])[CH:5]=[C:6]([F:10])[C:7]=1[O:8][CH3:9]

Participants

4

Reactant 3

HCID 73974-Toluenesulfonyl chlorideHCID 33557Sodium AzideHCID 14581311HCID 14581311, compound

Product 1

HCID 14581312HCID 14581312, compoundYield 95%

Procedure

3-(3,5-Difluoro-4-methoxyphenyl)propanol (0.073 mol), tosyl chloride (0.146 mol) and sodium azide (0.146 mol) were reacted substantially as described in Example 7E above to obtain 15.6 g (95%) yellow oil.

Sources & evidence

ORD record
ord-a80ab58594bf4f58b3622957123aeb59
Source dataset
uspto-grants-1989_03
Patent number
US04810811

Reaction notes

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