1-(3-Chloropropoxy)-4-fluorobenzene → HCID 14407087, compound

HRID 1193672Notes

Reaction equation

HRID 1193672 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:15]2[CH:20]=[CH:19][C:18]([F:21])=[CH:17][CH:16]=2)[CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)=[CH:4][CH:3]=1.Cl[CH2:23][CH2:24][CH2:25][O:26][C:27]1[CH:32]=[CH:31][C:30]([F:33])=[CH:29][CH:28]=1>>[F:21][C:18]1[CH:17]=[CH:16][C:15]([CH:8]([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[CH:9]2[CH2:14][CH2:13][N:12]([CH2:23][CH2:24][CH2:25][O:26][C:27]3[CH:28]=[CH:29][C:30]([F:33])=[CH:31][CH:32]=3)[CH2:11][CH2:10]2)=[CH:20][CH:19]=1

Participants

3

Reactant 2

HCID 743911-(3-Chloropropoxy)-4-fluorobenzeneHCID 132505444-[Bis(4-fluorophenyl)methyl]piperidine

Product 1

HCID 14407087HCID 14407087, compoundYield 53%

Procedure

Following the combined procedures of Examples 14 and 16, 4-[bis(4-fluorophenyl)methyl]piperidine and 4-(3-chloropropoxy)-1-fluorobenzene were reacted and worked up by chromatography in Example 16, to give the free base in 53% yield as a yellow oil after drying in vacuo at 80° C. overnight.

Workup

  1. customwere reacted
  2. customto give the free base in 53% yield as a yellow oil
  3. customafter drying in vacuo at 80° C. overnight

Sources & evidence

ORD record
ord-c3748be4a5c448a29e5453ea5bc20e17
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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