HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 4-[3-[4-[Bis(4-methoxyphenyl)methyl]-1-piperidinyl]propoxy]benzoic acid ethyl ester fumarate hydrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | 4-[Bis(4-methoxyphenyl)methyl]piperidine | HCID 14407167 | — |
| Reactant | Ethyl 4-(3-chloropropoxy)benzoate | HCID 18348522 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Product | 4-[3-[4-[Bis(4-methoxyphenyl)methyl]-1-piperidinyl]propoxy]benzoic acid ethyl ester fumarate hydrate | HCID 70373333 | — |
Reaction Steps
Following the procedure of Example 22, but substituting dimethylformamide at 73° C. for butanol, 4-[bis(4-methoxyphenyl)methyl]piperidine and 4-(3-chloropropoxy)benzoic acid ethyl ester were reacted to give the free base of the title compound which was reacted with fumaric acid, to give the white fumarate salt (recrystallizing from methanoldiethyl ether) in 27% yield, m.p. 147.5°-148.5° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-16a41b2c2b374449a63b131dcf11d5bb |
| Source note | uspto-grants-1989_03 |