HRID1193682

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID14407167

未命名化合物

HCID18348522

Ethyl 4-(3-chloropropoxy)benzoate

C12H15ClO3

PRODUCTS

生成物

结构：CCOC(=O)c1ccc(OCCCN2CCC(C(c3ccc(OC)cc3)c3ccc(OC)cc3)CC2)cc1.O.O=C(O)/C=C/C(=O)O

HCID70373333

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID263

1-Butanol

C4H10O

PROCEDURE

实验过程

Following the procedure of Example 22, but substituting dimethylformamide at 73° C. for butanol, 4-[bis(4-methoxyphenyl)methyl]piperidine and 4-(3-chloropropoxy)benzoic acid ethyl ester were reacted to give the free base of the title compound which was reacted with fumaric acid, to give the white fumarate salt (recrystallizing from methanoldiethyl ether) in 27% yield, m.p. 147.5°-148.5° C.

WORKUP

后处理

customat 73° C.
customwere reacted

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-16a41b2c2b374449a63b131dcf11d5bb
来源数据集: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04810713
来源说明: uspto-grants-1989_03

反应 SMILES

CN(C)[CH:3]=[O:4].[CH3:6][O:7][C:8]1[CH:13]=[CH:12][C:11]([CH:14]([C:21]2[CH:26]=[CH:25][C:24]([O:27][CH3:28])=[CH:23][CH:22]=2)[CH:15]2[CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)=[CH:10][CH:9]=1.[CH2:29]([O:31][C:32](=[O:44])[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42]Cl)=[CH:35][CH:34]=1)[CH3:30]>C(O)CCC>[OH2:4].[C:3]([OH:4])(=[O:7])/[CH:34]=[CH:33]/[C:32]([OH:44])=[O:31].[CH2:29]([O:31][C:32](=[O:44])[C:33]1[CH:38]=[CH:37][C:36]([O:39][CH2:40][CH2:41][CH2:42][N:18]2[CH2:19][CH2:20][CH:15]([CH:14]([C:21]3[CH:22]=[CH:23][C:24]([O:27][CH3:28])=[CH:25][CH:26]=3)[C:11]3[CH:10]=[CH:9][C:8]([O:7][CH3:6])=[CH:13][CH:12]=3)[CH2:16][CH2:17]2)=[CH:35][CH:34]=1)[CH3:30]