Bis(4-fluorophenyl)(piperidin-4-yl)methanol → HCID 14407116, compound

HRID 1193685Notes

Reaction equation

HRID 1193685 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=1>[I-].[K+]>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([CH:10]2[CH2:11][CH2:12][N:13]([CH2:24][CH2:25][CH2:26][O:27][C:28]3[CH:33]=[CH:32][C:31]([N+:34]([O-:36])=[O:35])=[CH:30][CH:29]=3)[CH2:14][CH2:15]2)[OH:9])=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 118446171-(3-Chloropropoxy)-4-nitrobenzene

Product 1

HCID 14407116HCID 14407116, compoundYield 72.5%

Reagents, catalysts & solvents 1

HCID 4875Potassium IodideCatalyst

Procedure

Following the procedure of Example 1 and using potassium iodide catalyst, a mixture of 9.1 g (0.03 mole) of [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and 6.7 g (0.03 mole) of 1-(3-chloropropoxy)-4-nitrobenzene were reacted to give 10.5 g of the title compound which was recrystallized from isopropyl ether, m.p. 93.5°-94.5° C.

Workup

  1. customwere reacted

Sources & evidence

ORD record
ord-ecebba50066e4be49c7f420698d0a3cb
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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