HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Iodide → HCID 14407123, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | Bis(4-fluorophenyl)(piperidin-4-yl)methanol | HCID 11208889 | — |
| Reactant | 1-[4-(4-Bromobutoxy)3-methoxyphenyl]ethanone | HCID 14407171 | — |
| Reactant | HCID 45259377 | HCID 45259377 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 14407123 | HCID 14407123 | — |
Reaction Steps
This compound was prepared according to the procedure used to synthesize the compound of Example 35. A mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 3.0 g (0.01 mole) of 1-[4-(4-bromobutoxy)-3-methoxyphenyl]ethanone, 5.3 g (0.05 mole of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of dimethylformamide gave, after purification by column chromatography on Florasil® (acetone-benzene). 0.8 g (15%) of off-white powder, m.p. 104°-105° C. after recrystallization from 2-propanol-isopropyl ether.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04810713 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-5e9bbd31e2034e18bac4e887029d1e16 |
| Source note | uspto-grants-1989_03 |