Potassium Iodide → HCID 14407123, compound

HRID 1193691Notes

Reaction equation

HRID 1193691 reaction equation
Cl.C(OC(=O)C1C=CC(OC[CH2:14][CH2:15][N:16]2[CH2:21][CH2:20][CH:19]([C:22]([C:31]3[CH:36]=[CH:35][C:34]([F:37])=[CH:33][CH:32]=3)([C:24]3[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=3)[OH:23])[CH2:18][CH2:17]2)=CC=1)C.FC1C=CC(C(C2C=CC(F)=CC=2)(C2CCNCC2)O)=CC=1.BrCC[CH2:64][CH2:65][O:66][C:67]1[CH:72]=[CH:71][C:70]([C:73](=[O:75])[CH3:74])=[CH:69][C:68]=1[O:76][CH3:77].C(=O)([O-])[O-].[Na+].[Na+].[I-].[K+]>CN(C)C=O>[F:37][C:34]1[CH:35]=[CH:36][C:31]([C:22]([C:24]2[CH:29]=[CH:28][C:27]([F:30])=[CH:26][CH:25]=2)([OH:23])[CH:19]2[CH2:20][CH2:21][N:16]([CH2:15][CH2:14][CH2:64][CH2:65][O:66][C:67]3[CH:72]=[CH:71][C:70]([C:73](=[O:75])[CH3:74])=[CH:69][C:68]=3[O:76][CH3:77])[CH2:17][CH2:18]2)=[CH:32][CH:33]=1

Participants

7

Reactant 5

HCID 4875Potassium IodideHCID 10340Sodium CarbonateHCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 144071711-[4-(4-Bromobutoxy)3-methoxyphenyl]ethanoneHCID 45259377HCID 45259377, compound

Product 1

HCID 14407123HCID 14407123, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This compound was prepared according to the procedure used to synthesize the compound of Example 35. A mixture of 3.0 g (0.01 mole) of α,α-bis(p-fluorophenyl)-4-piperidinemethanol, 3.0 g (0.01 mole) of 1-[4-(4-bromobutoxy)-3-methoxyphenyl]ethanone, 5.3 g (0.05 mole of anhydrous sodium carbonate and 0.3 g of potassium iodide in 100 ml of dimethylformamide gave, after purification by column chromatography on Florasil® (acetone-benzene). 0.8 g (15%) of off-white powder, m.p. 104°-105° C. after recrystallization from 2-propanol-isopropyl ether.

Workup

  1. customThis compound was prepared
  2. customgave
  3. customafter purification by column chromatography on Florasil® (acetone-benzene)
  4. custom0.8 g (15%) of off-white powder, m.p. 104°-105° C. after recrystallization from 2-propanol-isopropyl ether

Sources & evidence

ORD record
ord-5e9bbd31e2034e18bac4e887029d1e16
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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