Bis(4-fluorophenyl)(piperidin-4-yl)methanol → 1-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone

HRID 1193702Notes

Reaction equation

HRID 1193702 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.[C:23]([C:26]1[CH:36]=[CH:35][C:29]([O:30][CH2:31][CH2:32][CH2:33]Cl)=[CH:28][C:27]=1[O:37][CH3:38])(=[O:25])[CH3:24]>>[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([OH:9])[CH:10]2[CH2:11][CH2:12][N:13]([CH2:33][CH2:32][CH2:31][O:30][C:29]3[CH:35]=[CH:36][C:26]([C:23](=[O:25])[CH3:24])=[C:27]([O:37][CH3:38])[CH:28]=3)[CH2:14][CH2:15]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 144071823-(p-Acetyl-m-methoxyphenoxy)propyl chloride

Product 1

HCID 144071401-[4-[3-[4-[Bis(4-fluorophenyl)hydroxymethyl]-1-piperidinyl]propoxy]-2-methoxyphenyl]ethanone

Procedure

Following the procedure of Examples 1 and 66, [α,α-bis (p-fluorophenyl)]-4-piperidinemethanol and 3-(p-acetyl-m-methoxyphenoxy)propyl chloride are reacted to give the title compound.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-0dffa5b5d017482bbcb26afb8277520d
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

Loading…