Bis(4-fluorophenyl)(piperidin-4-yl)methanol → HCID 23036249, compound

HRID 1193703Notes

Reaction equation

HRID 1193703 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:16]2[CH:21]=[CH:20][C:19]([F:22])=[CH:18][CH:17]=2)([CH:10]2[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[OH:9])=[CH:4][CH:3]=1.Cl[CH2:24][CH2:25][CH2:26][O:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][C:29]=1[O:34][CH2:35][C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>[I-].[K+]>[CH2:35]([O:34][C:29]1[CH:30]=[CH:31][CH:32]=[CH:33][C:28]=1[O:27][CH2:26][CH2:25][CH2:24][N:13]1[CH2:12][CH2:11][CH:10]([C:8]([C:16]2[CH:17]=[CH:18][C:19]([F:22])=[CH:20][CH:21]=2)([C:5]2[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=2)[OH:9])[CH2:15][CH2:14]1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1

Participants

4

Reactant 2

HCID 11208889Bis(4-fluorophenyl)(piperidin-4-yl)methanolHCID 23036250HCID 23036250, compound

Product 1

HCID 23036249HCID 23036249, compound

Reagents, catalysts & solvents 1

HCID 4875Potassium IodideCatalyst

Procedure

Following the procedure of Example 2 and using potassium iodide catalyst, [α,α-bis(p-fluorophenyl)]-4-piperidinemethanol and 2-(3-chloropropoxy)-1-benzyloxybenzene are reacted to give 1-[3-(2-benzyloxyphenoxy)propyl]-α,α-bis(4-fluorophenyl)-4-piperidinemethanol which is reacted with hydrogen over palladium on carbon catalyst to give the title compound.

Workup

  1. customare reacted

Sources & evidence

ORD record
ord-86ad3cd5f3ca42a3936c90f197704d51
Source dataset
uspto-grants-1989_03
Patent number
US04810713

Reaction notes

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