Sodium ethoxide → HCID 21270769, compound

HRID 1193872Notes

Reaction equation

HRID 1193872 reaction equation
[Cl:1][C:2]1[CH:12]=[C:11]([F:13])[C:10]([N:14]2[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[N:16]=[C:15]2Cl)=[CH:9][C:3]=1[C:4]([O:6][CH2:7][CH3:8])=[O:5].[CH3:26][CH2:27][O-:28].[Na+]>C(O)C>[CH2:27]([O:28][C:15]1[N:14]([C:10]2[C:11]([F:13])=[CH:12][C:2]([Cl:1])=[C:3]([CH:9]=2)[C:4]([O:6][CH2:7][CH3:8])=[O:5])[C:19](=[O:20])[CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[N:16]=1)[CH3:26]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 21270749HCID 21270749, compound

Product 1

HCID 21270769HCID 21270769, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using ethyl 2-chloro-5-[2-chloro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and sodium ethylate in ethanol there is obtained ethyl 5-[2-ethoxy-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-2-chloro-4-fluorobenzoate, m.p. 94°-96° C.;

Sources & evidence

ORD record
ord-0662db6b030f4e3b871aa1c8800996fb
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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