Sodium ethoxide → HCID 21270796, compound

HRID 1193874Notes

Reaction equation

HRID 1193874 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:28])([F:27])[C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH3:30][CH2:31][O-].[Na+]>C(O)C>[CH2:30]([C:16]1[N:15]([C:11]2[C:12]([F:14])=[CH:13][C:2]([Cl:1])=[C:3]([CH:10]=2)[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5])[C:20](=[O:21])[CH:19]=[C:18]([C:22]([F:28])([F:27])[C:23]([F:24])([F:26])[F:25])[N:17]=1)[CH3:31]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 21270698HCID 21270698, compound

Product 1

HCID 21270796HCID 21270796, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using isopropyl 2-chloro-5-[2-chloro-6-oxo-4-pentafluoroethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and sodium ethylate in ethanol there is obtained isopropyl 5-[2-ethyl-6-oxo-4-pentafluoroethyl-1(6H)-pyrimidinyl]-2-chloro- 4-fluorobenzoate, 1H-NMR (CDCl3, 400 MHz): 7.83 ppm (d,1H), 7.39 ppm (d,1H), 6.65 ppm (s,1H), 5.72 ppm (m,1H), 4.48 ppm (m,2H), 1.38 ppm (d,3H), 1.37 ppm (d,3H), 1.29 ppm (t,3H);

Sources & evidence

ORD record
ord-320af9b115a349c7bfecd1c1c552822d
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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