Sodium ethoxide → HCID 21270750, compound

HRID 1193880Notes

Reaction equation

HRID 1193880 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[N:17]=[C:16]2Cl)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].[CH3:28][CH2:29][O-:30].[Na+]>C(O)C>[CH2:29]([O:30][C:16]1[N:15]([C:11]2[C:12]([F:14])=[CH:13][C:2]([Cl:1])=[C:3]([CH:10]=2)[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5])[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:26])([F:25])[F:24])[N:17]=1)[CH3:28]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 21270725HCID 21270725, compound

Product 1

HCID 21270750HCID 21270750, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using isopropyl 2-chloro-5-[2-chloro-5-fluoro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-4-fluorobenzoate and sodium ethylate in ethanol there is obtained isopropyl 5-[2-ethoxy-5-fluoro-6-oxo-4-trifluoromethyl-1(6H)-pyrimidinyl]-2-chloro-4-fluorobenzoate, 1H-NMR (CDCl3, 400 MHz): 7.83 ppm (d,1H), 7.40 ppm (d,1H), 5.27 ppm (m,1H), 4.48 ppm (m,2H), 1.39 ppm (d,3H), 1.38 ppm (d,3H), 1.29 ppm (t,3H);

Sources & evidence

ORD record
ord-dffac16825344e17853ca76e801acc49
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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