HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium → 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium | HCID 5360545 | — |
| Reactant | 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone | HCID 21270778 | — |
| Solvent | 1-Propanol | HCID 1031 | — |
| Product | 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone | HCID 21270699 | — |
Reaction Steps
using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and sodium propylate in n-propanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.31 ppm (d,1H), 6.80 ppm (d,1H), 6.59 ppm (s,1H), 4.31-4.51 ppm (m,3H), 1.67 ppm (m,2H), 1.38 ppm (d,3H), 1.37 ppm (d,3H), 0.85 ppm (t,3H);
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04812164 |
| Source dataset | uspto-grants-1989_03 |
| ORD ID | ord-2078a65960ab476aa8e69c7ff9817a41 |
| Source note | uspto-grants-1989_03 |