Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1193881Generated: October 27, 2026

Sodium → 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone

https://huagongshe.com/reaction/1193881

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodiumHCID 5360545—
Reactant2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinoneHCID 21270778—
Solvent1-PropanolHCID 1031—
Product1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinoneHCID 21270699—

Reaction Steps

using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and sodium propylate in n-propanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.31 ppm (d,1H), 6.80 ppm (d,1H), 6.59 ppm (s,1H), 4.31-4.51 ppm (m,3H), 1.67 ppm (m,2H), 1.38 ppm (d,3H), 1.37 ppm (d,3H), 0.85 ppm (t,3H);

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS04812164
Source datasetuspto-grants-1989_03
ORD IDord-2078a65960ab476aa8e69c7ff9817a41
Source noteuspto-grants-1989_03