Sodium → 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone

HRID 1193881Notes

Reaction equation

HRID 1193881 reaction equation
Cl[C:2]1[N:3]([C:13]2[CH:18]=[C:17]([O:19][CH:20]([CH3:22])[CH3:21])[C:16]([Cl:23])=[CH:15][C:14]=2[F:24])[C:4](=[O:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=1.[Na]>C(O)CC>[Cl:23][C:16]1[C:17]([O:19][CH:20]([CH3:22])[CH3:21])=[CH:18][C:13]([N:3]2[C:4](=[O:12])[CH:5]=[C:6]([C:8]([F:11])([F:10])[F:9])[N:7]=[C:2]2[O:12][CH2:4][CH2:5][CH3:6])=[C:14]([F:24])[CH:15]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 212707782-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone

Product 1

HCID 212706991-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent

Procedure

using 2-chloro-1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone and sodium propylate in n-propanol there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-propoxy-4-trifluoromethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.31 ppm (d,1H), 6.80 ppm (d,1H), 6.59 ppm (s,1H), 4.31-4.51 ppm (m,3H), 1.67 ppm (m,2H), 1.38 ppm (d,3H), 1.37 ppm (d,3H), 0.85 ppm (t,3H);

Sources & evidence

ORD record
ord-2078a65960ab476aa8e69c7ff9817a41
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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