Sodium ethoxide → HCID 21270761, compound

HRID 1193884Notes

Reaction equation

HRID 1193884 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=[C:13]2Cl)=[C:4]([F:24])[CH:3]=1.[CH3:25][CH2:26][O-:27].[Na+]>C(O)C>[CH2:26]([O:27][C:13]1[N:12]([C:5]2[CH:6]=[C:7]([O:8][CH:9]([CH3:11])[CH3:10])[C:2]([Br:1])=[CH:3][C:4]=2[F:24])[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=1)[CH3:25]

Participants

4

Reactant 2

HCID 2723922Sodium ethoxideHCID 21270795HCID 21270795, compound

Product 1

HCID 21270761HCID 21270761, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

using 1-(4-bromo-2-fluoro-5-isopropoxyphenyl)-2-chloro-4-trifluoromethyl-6(1H)-pyrimidinone and sodium ethylate in ethanol there is obtained 2-ethoxy-1-(4-bromo-2-fluoro-5 -isopropoxyphenyl)-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 106°-108° C.;

Sources & evidence

ORD record
ord-022836e467f549899fd9ac557d3dcd0a
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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