Dimethyl Sulfate → HCID 21270748, compound

HRID 1193891Notes

Reaction equation

HRID 1193891 reaction equation
[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:25])([F:24])[C:20]([F:23])([F:22])[F:21])[NH:14][C:13]2=[O:26])=[C:4]([F:27])[CH:3]=1.[C:28](=O)(O)[O-].[Na+].S(OC)(OC)(=O)=O>CC(C)=O>[Cl:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:25])([F:24])[C:20]([F:23])([F:21])[F:22])[N:14]=[C:13]2[O:26][CH3:28])=[C:4]([F:27])[CH:3]=1

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 516892Sodium BicarbonateHCID 21270715HCID 21270715, compound

Product 1

HCID 21270748HCID 21270748, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-6-pentafluoroethyl-2,4(1H,3H)-pyrimidinedione with sodium bicarbonate and dimethyl sulphate in acetone there is obtained 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-2-methoxy -4-pentafluoroethyl-6(1H)-pyrimidinone, m.p. 79°-81° C.;

Sources & evidence

ORD record
ord-49310f3418b34acf8ba93bf63991c9d0
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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