Dimethyl Sulfate → HCID 53722627, compound

HRID 1193903Notes

Reaction equation

HRID 1193903 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([OH:21])[C:18]([Cl:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:12])[F:11])[N:9]=1)[CH3:2].S(OC)(O[CH3:28])(=O)=O.C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH2:1]([O:3][C:4]1[N:5]([C:15]2[CH:20]=[C:19]([O:21][CH3:28])[C:18]([Cl:22])=[CH:17][C:16]=2[F:23])[C:6](=[O:14])[CH:7]=[C:8]([C:10]([F:13])([F:11])[F:12])[N:9]=1)[CH3:2]

Participants

5

Reactant 3

HCID 6497Dimethyl SulfateHCID 10340Sodium CarbonateHCID 21270727HCID 21270727, compound

Product 1

HCID 53722627HCID 53722627, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5 -hydroxyphenyl) -4-trifluoromethyl-6(1H)-pyrimidinone and dimethyl sulphate with sodium carbonate in acetone there is obtained 2-ethoxy-1-(4-chloro-2-fluoro-5 -methoxyphenyl) -4-trifluoromethyl-6(1H)-pyrimidinone. m.p. 117°-119° C.;

Sources & evidence

ORD record
ord-30aeec422cc54fac901a0806b42fb1b1
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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