Propargyl bromide → HCID 21270702, compound

HRID 1193906Notes

Reaction equation

HRID 1193906 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:18]2[CH:23]=[C:22]([OH:24])[C:21]([Cl:25])=[CH:20][C:19]=2[F:26])[C:6](=[O:17])[CH:7]=[C:8]([C:10]([F:16])([F:15])[C:11]([F:14])([F:13])[F:12])[N:9]=1)[CH3:2].[CH2:27](Br)[C:28]#[CH:29].C(=O)([O-])[O-].[Na+].[Na+]>CC(C)=O>[CH2:1]([O:3][C:4]1[N:5]([C:18]2[CH:23]=[C:22]([O:24][CH2:29][C:28]#[CH:27])[C:21]([Cl:25])=[CH:20][C:19]=2[F:26])[C:6](=[O:17])[CH:7]=[C:8]([C:10]([F:16])([F:15])[C:11]([F:12])([F:13])[F:14])[N:9]=1)[CH3:2]

Participants

5

Reactant 3

HCID 7842Propargyl bromideHCID 10340Sodium CarbonateHCID 21270730HCID 21270730, compound

Product 1

HCID 21270702HCID 21270702, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5 -hydroxyphenyl) -4-pentafluoroethyl-6(1H)-pyrimidinone and propargyl bromide with sodium carbonate in acetone there is obtained 2-ethoxy-1-[4-chloro-2-fluoro-5 -(2-propynyloxy)-phenyl]-4-pentafluoroethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.35 ppm (d,1H), 6.98 ppm (d,1H), 6.65 ppm (s,1H), 4.77 ppm (m,2H), 4.48 ppm (m,2H), 2.57 ppm (t,1H), 1.29 ppm (t,3H);

Sources & evidence

ORD record
ord-daa7a8a4700e41ebb55f8aa2dc1918c1
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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