Propargyl bromide → HCID 21270702, compound

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Reaction Steps

using 2-ethoxy-1-(4-chloro-2-fluoro-5 -hydroxyphenyl) -4-pentafluoroethyl-6(1H)-pyrimidinone and propargyl bromide with sodium carbonate in acetone there is obtained 2-ethoxy-1-[4-chloro-2-fluoro-5 -(2-propynyloxy)-phenyl]-4-pentafluoroethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 400 MHz): 7.35 ppm (d,1H), 6.98 ppm (d,1H), 6.65 ppm (s,1H), 4.77 ppm (m,2H), 4.48 ppm (m,2H), 2.57 ppm (t,1H), 1.29 ppm (t,3H);

Provenance & Evidence