Pyridine → HCID 53892817, compound

HRID 1193908Notes

Reaction equation

HRID 1193908 reaction equation
[CH2:1]([O:3][C:4]1[N:5]([C:18]2[CH:23]=[C:22]([OH:24])[C:21]([Cl:25])=[CH:20][C:19]=2[F:26])[C:6](=[O:17])[CH:7]=[C:8]([C:10]([F:16])([F:15])[C:11]([F:14])([F:13])[F:12])[N:9]=1)[CH3:2].Cl[C:28]([O:30][CH2:31][CH2:32][O:33][CH3:34])=[O:29].N1C=CC=CC=1>C(OCC)C>[C:28](=[O:29])([O:30][CH2:31][CH2:32][O:33][CH3:34])[O:24][C:22]1[CH:23]=[C:18]([N:5]2[C:6](=[O:17])[CH:7]=[C:8]([C:10]([F:16])([F:15])[C:11]([F:12])([F:13])[F:14])[N:9]=[C:4]2[O:3][CH2:1][CH3:2])[C:19]([F:26])=[CH:20][C:21]=1[Cl:25]

Participants

5

Reactant 3

HCID 1049PyridineHCID 694002-Methoxyethyl chloroformateHCID 21270730HCID 21270730, compound

Product 1

HCID 53892817HCID 53892817, compound

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent

Procedure

using 2-ethoxy-1-(4-chloro-2-fluoro-5-hydroxyphenyl)-4-pentafluoroethyl-6(1H)-pyrimidinone and 2-methoxyethyl chloroformate with pyridine in diethyl ether there is obtained {5-[2-ethoxy-6-oxo-4-pentafluoroethyl-1(6H) -pyrimidinyl]-2-chloro-4-fluorophenyl} 2-methoxyethyl carbonate, 1H-NMR (CDCl3, 400 MHz): 7.39 ppm (d,1H), 7.26 ppm (d,1H), 6.64 ppm (s,1H), 4.39°-4.56 ppm (m,4H), 3.70 ppm (m,2H), 3.43 ppm (s,3H), 1.30 ppm (t,3H):

Sources & evidence

ORD record
ord-3175c368aa5c4d509deb269ca1a2b15f
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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