Sulfuric Acid → HCID 21270789, compound

HRID 1193932Notes

Reaction equation

HRID 1193932 reaction equation
[Cl:1][C:2]1[C:7]([O:8]C(C)C)=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([C:20]([F:26])([F:25])[C:21]([F:24])([F:23])[F:22])[N:14]=[C:13]2[O:27][CH3:28])=[C:4]([F:29])[CH:3]=1.S(=O)(=O)(O)O>>[Cl:1][C:2]1[C:7]([OH:8])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[C:16]([F:19])=[C:15]([C:20]([F:25])([F:26])[C:21]([F:23])([F:22])[F:24])[N:14]=[C:13]2[O:27][CH3:28])=[C:4]([F:29])[CH:3]=1

Participants

3

Reactant 2

HCID 1118Sulfuric AcidHCID 21270709HCID 21270709, compound

Product 1

HCID 21270789HCID 21270789, compound

Procedure

using 1-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-2-methoxy-4-pentafluoroethyl-6(1H)-pyrimidinone with concentrated sulphuric acid during 2 minutes at 0° C. there is obtained 1-(4-chloro-2-fluoro-5-hydroxyphenyl)-5-fluoro-2-methoxy-4-pentafluoroethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 60 MHz): 7.28 ppm (d,1H), 6.83 ppm (d,1H), 5.10 ppm (s,1H), 4.00 ppm (s,3H);

Workup

  1. customduring 2 minutes
  2. customat 0° C.

Sources & evidence

ORD record
ord-bd56a4577934417eade2ff7373aef76f
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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