Phosphorus oxychloride → HCID 21270795, compound

HRID 1193939Notes

Reaction equation

HRID 1193939 reaction equation
[Br:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[NH:14][C:13]2=O)=[C:4]([F:24])[CH:3]=1.P(Cl)(Cl)([Cl:27])=O>N1C=CC=CC=1>[Br:1][C:2]1[C:7]([O:8][CH:9]([CH3:11])[CH3:10])=[CH:6][C:5]([N:12]2[C:17](=[O:18])[CH:16]=[C:15]([C:19]([F:22])([F:21])[F:20])[N:14]=[C:13]2[Cl:27])=[C:4]([F:24])[CH:3]=1

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 20025935HCID 20025935, compound

Product 1

HCID 21270795HCID 21270795, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

using 3-(4-bromo-2-fluoro-5-isopropoxyphenyl)-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with phosphorus oxychloride and pyridine there is obtained 1-(4-bromo-2-fluoro-5-isopropoxyphenyl)-2-chloro-4-trifluoromethyl-6(1H)-pyrimidinone, m.p. 102° C.;

Sources & evidence

ORD record
ord-d57968c2421243aa80dc4be9b90c5ba7
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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