反应详情

using 3-(4-chloro-2-fluoro-5-isopropoxyphenyl)-5-fluoro-6-trifluoromethyl-2,4(1H,3H)-pyrimidinedione with phosphorus oxychloride and pyridine within 15 minutes at 20°-40° C. and thereafter for 1 hour at 70° C. there is obtained 2-chloro-1-(4-chloro-2-fluoro -5-isopropoxyphenyl)-5-fluoro-4-trifluoromethyl-6(1H)-pyrimidinone, 1H-NMR (CDCl3, 60 MHz): 7.42 ppm (d,1H), 6.84 ppm (d,1H), 4.50 ppm (m,1H), 1.44 ppm (d,6H);

1. customwithin 15 minutes
2. customat 20°-40° C.