Phosphorus oxychloride → HCID 21270766, compound

HRID 1193941Notes

Reaction equation

HRID 1193941 reaction equation
[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[NH:17][C:16]2=O)=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:9])[CH3:8])=[O:5].P(Cl)(Cl)([Cl:33])=O>N1C=CC=CC=1>[Cl:1][C:2]1[CH:13]=[C:12]([F:14])[C:11]([N:15]2[C:20](=[O:21])[C:19]([F:22])=[C:18]([C:23]([F:29])([F:28])[C:24]([F:27])([F:26])[F:25])[N:17]=[C:16]2[Cl:33])=[CH:10][C:3]=1[C:4]([O:6][CH:7]([CH3:8])[CH3:9])=[O:5]

Participants

4

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 21270753HCID 21270753, compound

Product 1

HCID 21270766HCID 21270766, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

using isopropyl 2-chloro-5-[3,6-dihydro-2,6-dioxo-5-fluoro-4-pentafluoroethyl-1(2H)-pyrimidinyl]-4-fluorobenzoate with phosphorus oxychloride and pyridine within 6 hours at room temperature there is obtained isopropyl 2-chloro-5-[2-chloro-5-fluoro-6-oxo-4-pentafluoroethyl-1(6H) -pyrimidinyl]-4-fluorobenzoate, 1H-NMR (CDCl3, 400 MHz): 7.88 ppm (d,1H), 7.48 ppm (d,1H), 5.28 ppm (m,1H), 1.39 ppm (d,6H),

Workup

  1. customwithin 6 hours
  2. customat room temperature

Sources & evidence

ORD record
ord-a2916b6127da4dc987b774e6aa09be86
Source dataset
uspto-grants-1989_03
Patent number
US04812164

Reaction notes

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