Hydrochloric Acid → 102822-61-7

HRID 1193951Notes

Reaction equation

Cl.[C:2]([NH:5][C@:6]([CH3:14])([C:11](O)=[O:12])[CH2:7][CH:8]([CH3:10])[CH3:9])(=[O:4])[NH2:3]>>[CH3:14][C@:6]1([CH2:7][CH:8]([CH3:10])[CH3:9])[C:11](=[O:12])[NH:3][C:2](=[O:4])[NH:5]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 18631265HCID 18631265, compound

Product 1

HCID 1810193102822-61-7

Conditions

Temperature: 80 °C

Procedure

Water phase treated with ethyl acetate extraction was adjusted to a pH value of 1.0 and again extracted with 100 ml×2 of ethyl acetate. After distilling away ethyl acetate from an extract under reduced pressure, 1.10 g of (S)-N-carbamoyl-α-methylleucine was obtained as a white crystal [α]D25 =+8.0 (c=0.5, 0.1N NaOH)). To 25 ml of a 2N aqueous solution of HCl was added 1.00 g of the thus obtained (S)-N-carbamoyl-α-methylleucine and a mixture was heated at 80° C. for 2 hours in order to cyclize to give 0.83 g of (S)-4-methyl-4-isobutylimidazolidine-2,5-dione as a white crystal.

Sources & evidence

ORD record: ord-b69a8f83be49473a8a3971e42150e930
Source dataset: uspto-grants-1989_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04812406

Reaction notes

Loading…