Dichloromethane → 2-Fluoro-2-(3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)acetaldehyde

HRID 119396Notes

Reaction equation

HRID 119396 reaction equation
[Cl:40][CH2:41][Cl:42].[F:1][CH:2]([CH2:3][OH:4])[c:5]1[cH:6][c:7]([CH2:8][N:9]2[CH2:10][CH2:11][C:12]3([CH2:13][N:14]([C:18](=[O:19])[c:20]4[n:21][c:22]([CH:25]([CH3:26])[CH3:27])[s:23][cH:24]4)[CH2:15][CH2:16][O:17]3)[CH2:28][CH2:29]2)[cH:30][cH:31][cH:32]1.[OH:33][C:34]([C:35]([F:36])([F:37])[F:38])=[O:39]>>[F:1][CH:2]([CH:3]=[O:4])[c:5]1[cH:6][c:7]([CH2:8][N:9]2[CH2:10][CH2:11][C:12]3([CH2:13][N:14]([C:18](=[O:19])[c:20]4[n:21][c:22]([CH:25]([CH3:26])[CH3:27])[s:23][cH:24]4)[CH2:15][CH2:16][O:17]3)[CH2:28][CH2:29]2)[cH:30][cH:31][cH:32]1

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 6422Trifluoroacetic acidHCID 67292595(9-(3-(1-Fluoro-2-hydroxyethyl)benzyl)-1-oxa-4,9-diazaspiro[5.5]undecan-4-yl)(2-isopropylthiazol-4-yl)methanone

Product 1

HCID 579890482-Fluoro-2-(3-((4-(2-isopropylthiazole-4-carbonyl)-1-oxa-4,9-diazaspiro[5.5]undecan-9-yl)methyl)phenyl)acetaldehyde

Sources & evidence

ORD record
ord-a3d590286d1048abb8129289018d4181
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (2/10)

Reaction notes

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