Potassium Carbonate → HCID 178435433, compound

HRID 1193973Notes

Reaction equation

HRID 1193973 reaction equation
[OH:1][C:2]1[C:11]([OH:12])=[N:10][C:9]2[C:4](=[CH:5][C:6]([N+:19]([O-:21])=[O:20])=[C:7]([C:13]#[C:14][Si](C)(C)C)[CH:8]=2)[N:3]=1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:13]([C:7]1[CH:8]=[C:9]2[C:4](=[CH:5][C:6]=1[N+:19]([O-:21])=[O:20])[N:3]=[C:2]([OH:1])[C:11]([OH:12])=[N:10]2)#[CH:14]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 178504177HCID 178504177, compound

Product 1

HCID 178435433HCID 178435433, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A solution of 300 mg (0.99 mmol) 2,3-dihydroxy-6-trimethylsilylethynyl-7-nitroquinoxaline in 10 ml methanol is added 200 mg (1.45 mmol) potassium carbonate and then stirred at room temperature for 1 h. The reaction mixture is evaporated in vacuo and added water and 4N hydrochloric acid to pH 6. The precipitated product is filtered off and washed with water to give 200 mg (88%) of 6-ethynyl-2,3-dihydroxy-7-nitroquinoxaline m.p. >300° C.

Workup

  1. customThe reaction mixture is evaporated in vacuo
  2. additionadded water and 4N hydrochloric acid to pH 6
  3. filtrationThe precipitated product is filtered off
  4. washwashed with water

Sources & evidence

ORD record
ord-00d0c6d67a604b2d827b1c2d527f3682
Source dataset
uspto-grants-1989_03
Patent number
US04812458

Reaction notes

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